Southeast Ohio Vacations from $350

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Your Southeast Ohio Vacation

Choose a vacation package to Southeast Ohio and make planning your getaway quick and easy. With the logistics arranged before you depart, you can focus on enjoying every second in this destination. Begin your trip to Southeast Ohio with some time in Clarksville visiting popular sights like KFC Yum Center and Kentucky Kingdom. Athens is another city that lures crowds from far and wide. Fun Barn and Strouds Run State Park are two of the top places to see in this destination. Expedia is a one-stop shop for planning your Southeast Ohio vacation. From accommodations and flights, to car rentals and activities, we know how to create a travel experience like no other.

The Latest Southeast Ohio vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo Pittsburgh East Liberty by IHG
The Urbn Jungle
Jungle Casa Dos
The Westin Pittsburgh, a Marriott Hotel
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Discover the most popular places to visit in Southeast Ohio

Southeast Ohio Hotel Deals

Days Inn by Wyndham Columbus East Airport

Days Inn by Wyndham Columbus East Airport

2.5 out of 5
2100 Brice Road, Reynoldsburg, OH
$76 nightly
The price is $89 total per night from Aug 13 to Aug 14
$89 total
Aug 13 - Aug 14
Total includes taxes and fees
7/10 Good! (1,010 reviews)
Decent room for the price. No issues
"The room is older and not really updated. Had a problem figuring out the TV, But a note was left to figure it out. Bathroom Door Didn't close , but it was a decent room. People above me made a lot of noise, but not a fault of the hotel."

Reviewed on Aug 11, 2025

Days Inn by Wyndham Columbus East Airport
Ohio University Inn & Conference Center

Ohio University Inn & Conference Center

3.5 out of 5
331 Richland Ave, Athens, OH
$124 nightly
The price is $141 total per night from Aug 17 to Aug 18
$141 total
Aug 17 - Aug 18
Total includes taxes and fees
9/10 Wonderful! (1,007 reviews)
"The OU in is my favorite hotel!!! Their updates are so nice the rooms are always clean the staff is always helpful and friendly! The outdoor spaces are gorgeous and so fun to relax in! They’ve even thought of all the little touches like a water bottle filler in the lobby! We’ll be back again next ..."

Reviewed on Aug 10, 2025

Ohio University Inn & Conference Center
Christopher Inn and Suites

Christopher Inn and Suites

2.5 out of 5
30 North Plaza Boulevard, Chillicothe, OH
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $148 total per night from Sep 11 to Sep 12
$148 total
Sep 11 - Sep 12
Total includes taxes and fees
9/10 Wonderful! (1,007 reviews)
Best sleep and breakfast
"HIGHLY RECOMMEND! Most comfortable beds and bedding. Actual soap and shampoo- not the watered down dispensers. Best variety of breakfast options and hot food was actually hot! Did not use the pool but looked very nice."

Reviewed on Aug 9, 2025

Christopher Inn and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.